Hitchhiking Under Positive Darwinian Selection

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چکیده

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Hitchhiking under positive Darwinian selection.

Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present but rare, both deterministic and stochastic models of positive selection show that linked variation hitchhikes to either low or high frequencies. While the frequency distribution of variation can be i...

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Compound tests for the detection of hitchhiking under positive selection.

Many statistical tests have been developed for detecting positive selection. Most of these tests draw conclusions based on significant deviations from the patterns of polymorphism predicted by the neutral model. However, many non-equilibrium forces may cause similar deviations, and thus the tests usually have low statistical specificity to positive selection. The main challenge is hence to cons...

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A test for positive Darwinian selection

The neutral theory of molecular evolution maintains that most sequence variation among genomes has no direct relevance to adaptation [1]. The rapidly-growing amount of genomic data makes it possible now to ask which proteins are undergoing adaptive evolution. This, in turn calls for better computational tools to detect positive selection. In this study, we present a new test for detecting posit...

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Positive Darwinian Selection in Gene Evolution

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ژورنال

عنوان ژورنال: Genetics

سال: 2000

ISSN: 1943-2631

DOI: 10.1093/genetics/155.3.1405